A possible mechanism for vesicle formation by extrusion
نویسندگان
چکیده
منابع مشابه
The mechanism of vesicle formation.
Phospholipid molecules exhibit amphiphilic properties and therefore they aggregate either in their crystalline state or in polar solvents into ordered structures with typical lyotropic liquid crystalline symmetries (de Gennes, 1974). At high lipid concentrations in water these are predominantly lamellar phases (Luzzati, 1968), while in aqueous solutions phospholipid molecules normally form self...
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Clathrin-coated pits are the major ports of entry into the cell and are responsible for the internalization of a variety of biologically important macromolecules. These transport intermediates form as a result of the co-ordinated assembly of a number of cytosolic proteins on to the membrane which results in specific cargo recruitment. We have used a variety of approaches including permeabilized...
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The hypothalamus of adult male mice was investigated with the electron microscope. In all hypothalamic nuclei examined the nerve cells frequently contained nucleolus-like inclusion bodies in the cytoplasm. These inclusion bodies appeared to be composed of the same constituent particles as those of the intranuclear nucleolus. This permits consideration of their probable nuclear origin. The acces...
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Topologically associating domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, likely cohesins, form progressively larger loops but stall at TAD boundaries due to interactions wi...
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A mechanism for polarized transport of vesicles by means of osmotic propulsions is proposed and substantiated for tip-growing cells. An analysis is presented which shows that in pollen tubes the gradient of cytosolic water potential can drive vesicle movement either in the anterograde or retrograde direction, depending on the vesicle position, its radius and the phase of growth oscillation. The...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1994
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(94)80503-x